期刊
BIOMACROMOLECULES
卷 12, 期 1, 页码 1-5出版社
AMER CHEMICAL SOC
DOI: 10.1021/bm100922j
关键词
-
资金
- EPSRC (U.K.)
- Doctoral Training Centre
- Engineering and Physical Sciences Research Council [EP/D065046/1] Funding Source: researchfish
- EPSRC [EP/D065046/1] Funding Source: UKRI
Polymyxin peptide conjugated to the end groups of highly branched poly(N-isopropyl acrylamide) was shown to bind to a Gram negative bacterium, Pseudomonas aeruginosa. The nonbound polymer had a lower critical solution temperature (LCST) above 60 degrees C. However, binding caused aggregation, which was disrupted on cooling of the bacteria and polymer mixture. The data indicate that polymer binding of bacteria occurred by interaction of the end groups with lipopolysaccharide and that the binding decreased the LCST to below 37 degrees C. Cooling then progressed the polymer/bacteria aggregate through a bound LCST into an open polymer coil conformation that was riot adhesive to P. aeruginosa.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据