期刊
BIOMACROMOLECULES
卷 11, 期 12, 页码 3548-3555出版社
AMER CHEMICAL SOC
DOI: 10.1021/bm101020e
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资金
- Australian Research Council
We report the synthesis of poly(methacrylic acid)-co-(oleyl methacrylate) with three different amounts of oleyl methacrylate and compare the ability of these polymers with that of poly(methacrylic acid)-co-(cholesteryl methacrylate) (PMA(c)) to noncovalently anchor liposomes to polymer layers. We subsequently assembled similar to 1 mu m diameter PMA(c)-based capsosomes, polymer hydrogel capsules that contain up to similar to 2000 liposomal subcompartments, and investigate the potential of these carriers to deliver water-insoluble drugs by encapsulating two different antitumor compounds, thiocoraline or paclitaxel, into the liposomes. The viability of lung cancer cells is used to substantiate the cargo concentration-dependent activity of the capsosomes. These findings cover several crucial aspects for the application of capsosomes as potential drug delivery vehicles.
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