期刊
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
卷 278, 期 5, 页码 R1125-R1133出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpregu.2000.278.5.R1125
关键词
angiotensin II-receptor block; breath timing and drive; respiratory pattern; respiratory control; behavioral state; sleep
类别
Spontaneously hypertensive rats (SHR) have an activated brain angiotensin system. We hypothesized 1) that ventilation ((V) over dot) would be greater in conscious SHR than in control Wistar-Kyoto (WKY) rats and 2) that intravenous infusion of the ANG II-receptor blocker saralasin would depress respiration in SHR, but not in WKY. Respiration and oxygen consumption ((V) over dot O-2) were measured in conscious aged-matched groups (n = 16) of adult female SHR and WKY. For protocol 1, rats were habituated to a plethysmograph and measurements obtained over 60-75 min. After installation of chronic intravenous catheters, protocol 2 consisted of 30 min of saline infusion (similar to 14 mu l.kg(-1).min(-1)) followed by 30 min of saralasin (1.3 mu g.kg(-1).min(-1)). (V) over dot, tidal volume (VT), inspiratory flow [VT/inspiratory time (TI)], breath expiratory time, and (V) over O-2 were higher, and breath TI was lower in continuously quiet SHR. In SHR, but not in WKY rats, ANG II-receptor block decreased (V) over dot, VT, and VT/TI and increased breath TI. During ANG II-receptor block, an average decrease in (V) over dot O-2 in SHR was not significant. About one-half of the higher (V) over dot in SHR appears to be accounted for by an ANG II mechanism acting either via peripheral arterial receptors or circumventricular organs.
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