期刊
JOURNAL OF BIOCHEMISTRY
卷 127, 期 5, 页码 717-722出版社
OXFORD UNIV PRESS
DOI: 10.1093/oxfordjournals.jbchem.a022662
关键词
nuclear receptor; VDR KO mice; vitamin D; vitamin D 1 alpha-hydroxylase; transcription factor
Vitamin D has roles in a variety of biological actions such as calcium homeostasis, cell proliferation and cell differentiation to many target tissues. Most of these biological actions of vitamin D are now considered to be exerted through the nuclear vitamin D receptor (VDR)-mediated control of target genes. VDR belongs to the nuclear hormone receptor superfamily and acts as a ligand-inducible transcription factor. For the ligand-induced transactivation of VDR, coactivator complexes have recently been shown to be essential. The function of VDR as a ligand-induced transcription factor is overviewed, and the phenotype of VDR gene knock-out mice and the VDR-mediated transcriptional and negative regulation of the key enzyme in vitamin D biosynthesis are also described, based mainly on our recent findings, to gain a better understanding of the function of VDR in the transcriptional control of vitamin D target genes.
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