期刊
JOURNAL OF ANTIBIOTICS
卷 53, 期 5, 页码 459-466出版社
JAPAN ANTIBIOT RES ASSN
DOI: 10.7164/antibiotics.53.459
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In the course of our screening for inhibitors of sphingosine kinase, we found an active compound from a culture broth of a discomycete, Trichopezizella barbata SANK 25395. The structure of the compound, named F-12509A, was elucidated by a combination of spectroscopic analyses, to be a new sesquiterpene quinone consisting of a drimane moiety and a dihydroxybenzoquinone. Enzyme kinetic analyses showed that F-12509A inhibits sphingosine kinase activity in a competitive manner with respect to sphingosine, with a K-i value of 18 mu M.
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