期刊
BIOMACROMOLECULES
卷 11, 期 12, 页码 3480-3486出版社
AMER CHEMICAL SOC
DOI: 10.1021/bm100989x
关键词
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资金
- National Natural Science Foundation of China [20876018, 20736006]
- Chinese Academy of Sciences [KJCX2.YW.M02, KJCX2-YW-210-02]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
Novel amphiphilic chitosan derivatives (glycidol chitosan deoxycholic acid, G-CS-DCA) were synthesized by grafting hydrophobic moieties, deoxycholic acid (DCA), and hydrophilic moieties, glycidol, with the purpose of preparing carriers for poorly soluble drugs. Based on self-assembly. G-CS-DCA can form nanoparticles with size ranging from 160 to 210 nm, and G-CS-DCA nanoparticles maintained stable structure for about 3 months when stored in PBS (pH 7.4) at room temperature. The critical aggregation concentration decreased from 0.043 mg/mL to 0.013 mg/mL with the increase of degree of substitution (DS) of DCA. Doxorubicin (DOX) could be easily encapsulated into G-CS-DCA nanoparticles and keep a sustained release manner without burst release when exposed to PBS (pH 7.4) at 37 degrees C. Antitumor efficacy results showed that DOX-G-CS-DCA have significant antitumor activity when MCF-7 cells were incubated with different concentration of DOX-G-CS-DCA nanoparticles. The fluorescence imaging results indicated DOX-G-CS-DCA nanoparticles could easily be uptaken by MCF-7 cells. These results suggested that G-CS-DCA nanoparticles may be a promising carrier for DOX delivery in cancer therapy.
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