期刊
BIOMACROMOLECULES
卷 10, 期 10, 页码 2802-2808出版社
AMER CHEMICAL SOC
DOI: 10.1021/bm9006419
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资金
- Science and Technology Service
- Embassy of France in India
- INDIA
- French Ministry of Foreign affairs (MAE)
- LCPO
Using click chemistry as an easy and versatile synthetic strategy to combine hyaluronan and polyglutamate blocks, we have prepared nanovesicles (polymersomes) that present a controlled size, excellent colloidal stability, and a high loading capacity for hydrophilic and hydrophobic drugs. The unique feature of our concept is the use of hyaluronan, a polysaccharide with known capacity for targeting cancer-related protein receptors, as the hydrophilic portion of a block copolymer system. The cytotoxicity and internalization mechanism of doxorubicin-loaded polymersomes have been evaluated in C6 glioma tumor cell lines. The dual purpose served by hyaluronan, as both a hydrophilic block critical to vesicle formation and a binding agent for biological targets, breaks new ground in terms of multifunctional nanomaterial design for drug delivery.
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