期刊
IMMUNITY
卷 12, 期 5, 页码 471-481出版社
CELL PRESS
DOI: 10.1016/S1074-7613(00)80199-5
关键词
-
类别
资金
- NIAID NIH HHS [AI45073] Funding Source: Medline
CXCR5, the receptor for B lymphocyte chemoattractant (BLC), is required for normal development of Peyer's patches, inguinal lymph nodes, and splenic follicles. To test the in vivo activity of BLC in isolation of other lymphoid organizers, transgenic mice were generated expressing BLC in the pancreatic islets. In addition to attracting B cells, BLC expression led to development of lymph node-like structures that contained B and T cell zones, high endothelial venules, stromal cells, and the chemokine SLC. Development of these features was strongly dependent on B lymphocytes and on lymphotoxin alpha 1 beta 2 and could be reversed by blocking lymphotoxin alpha 1 beta 2. These findings establish that BLC is sufficient to activate a pathway of events leading to formation of organized lymphoid tissue.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据