期刊
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
卷 26, 期 7, 页码 783-789出版社
WILEY-BLACKWELL
DOI: 10.1111/jce.12684
关键词
antibiotic; cardiac implantable electronic device; cardiac resynchronization therapy; infection; pacemaker; defibrillator
资金
- St. Jude Medical
- Medtronic
- Boston Scientific
- Biosense Webster
Outcomes with Routine Use of Antimicrobial Envelope IntroductionInfection of cardiac implanted electrical devices (CIED) is a problem. In selected patients, use of an antibacterial envelope (AIGISRx (R)) is associated with low CIED infection rates. The value of this device when used as a standard of care is unclear. Methods and ResultsRetrospective analysis of all patients (N = 1,476) who underwent CIED implantation at a single hospital. During the study period, some implanters used the AIGISRx as a standard of care (Yes-AIGISRx Group, N = 365), whereas others did not use it at all (No-AIGISRx Group, N = 1,111). A risk score based on preoperative factors was calculated for each patient. Rates of CIED infection within 6 months were measured, and associated costs were estimated. The Yes-AIGISRx and No-AIGISRx groups had similar preoperative infection risk. In the No-AIGISRx group, 19 infections were observed (1.7%), versus 0 in the Yes-AIGISRx group (P = 0.006). The 6-month mortality rate among patients with infection was significantly greater than among those without infection (15.7% vs. 4.5%, P = 0.021). The average hospital duration for infection care was 13 days. By extrapolating the infection rate and costs observed in the No-AIGISRx group to the Yes-AIGISRx group, we estimated that there would have been 6.2 additional infections costing approximately $340,000. This cost was similar to the actual cost of the devices in the Yes-AIGISRx group, estimated at $320,000. ConclusionsStandard of care use of an antibacterial envelope as a standard of care was associated with a significantly lower rate of CIED infection, and appeared to be economically reasonable. Prospective trials to address these findings may be worthwhile.
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