期刊
BIOMATERIALS
卷 21, 期 10, 页码 1021-1029出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0142-9612(99)00271-9
关键词
polyurethanes; poly(dimethylsiloxane); environmental stress cracking (ESC); degradation; biostability
A series of four thermoplastic polyurethane elastomers were synthesized with varying proportions of poly(hexamethylene oxide) (PHMO) and poly(dimethylsiloxane) (PDMS) macrodiols. The macrodiol ratios (by weight) employed were (% PDMS: %PHMO) 100 :0, 80: 20, 50: 50 and 20: 80. The weight fraction of macrodiol in each polymer was fixed at 60%. The mixed macrodiols were reacted with 4,4'-methylenediphenyl diisocyanate (MDI) and 1,4-butanediol (BDO) chain extender. The biostability of these polymers was assessed by strained subcutaneous implantation in sheep for three months followed by microscopic examination. Pellethane 2363-80A and 2363-55D were employed as control materials. The mechanical properties of the polymers were tested and discussed along with the biostability results. The results showed that soft, flexible PDMS-based polyurethanes with very promising biostability can be successfully produced using the mixed macrodiol approach. The formulation with 80% PDMS macrodiol produced the best result in terms of a combination of flexibility, strength and biostability. (C) 2000 Elsevier Science Ltd. All rights reserved.
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