期刊
JOURNAL OF NEUROSURGERY
卷 92, 期 5, 页码 863-869出版社
AMER ASSOC NEUROLOGICAL SURGEONS
DOI: 10.3171/jns.2000.92.5.0863
关键词
Parkinson's disease; glial cell line-derived neurotrophic factor; neural transplantation; stereotactic neurosurgery
The authors have studied the ability of glial cell line-derived neurotrophic factor (GDNF) to promote survival of human fetal dopaminergic tissue after a storage period of 6 days and subsequent implantation into the human putamen. The results indicate that GDNF promotes survival of stored dopaminergic cells. Cells stored without GDNF had a 30.1% decrease in survival time compared with those exposed to GDNF. Two patients with Parkinson's disease received bilateral putaminal implants of fetal dopaminergic cells exposed to GDNF for 6 days and showed enhancement of graft survival as assessed by positron emission tomography scanning. A mean increase of 107% in putaminal fluoro-dopa uptake from baseline values was observed 12 months postgrafting.
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