期刊
DEVELOPMENT GENES AND EVOLUTION
卷 210, 期 5, 页码 258-262出版社
SPRINGER VERLAG
DOI: 10.1007/s004270050312
关键词
Frizzled; Wnt; polarity; cell signaling; hydra
资金
- NIDDK NIH HHS [DK47840] Funding Source: Medline
- NINDS NIH HHS [NS33320] Funding Source: Medline
The Wnt signaling pathway plays an important role in the specification of cell patterning during development in many species. Here we report the isolation and characterization of a putative Wnt receptor, Frizzled, in Hydra vulgaris. Analysis of the amino acid sequence of Frizzled in hydra reveals that this receptor contains many strong sequence similarities to other known Frizzled receptors. Hydra divergence is estimated to have occurred about one billion years ago; thus comparison of the Frizzled sequence of hydra with that of other species is likely to provide important information on the structure and function of those highly conserved regions. Northern and Southern blotting reveal that the Frizzled receptor in hydra has a 2.34-kb message size, and that it is encoded by a single gene. In situ hybridization using hydra frizzled as a probe reveals that the receptor message is restricted to the endoderm in adult hydra. This distribution supports the hypothesis that the Frizzled receptor is functioning in a pathway that controls cell differentiation in hydra.
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