期刊
BIOLOGY OF THE CELL
卷 104, 期 10, 页码 571-587出版社
WILEY
DOI: 10.1111/boc.201100109
关键词
DNA Methyltransferases; Genomic Imprinting; Histone; piRNA; Retrotransposons
类别
资金
- National Science Council, Taiwan [98-3111-B-002-002, 99-2314-B-002-108-MY3, 99-3111-B-002-008]
- National Taiwan University [97R0066-46, NTU-CESPR-10R70602D3]
DNA methyltransferase 3-like (DNMT3L) is one of the key players in de novo DNA methylation of imprinting control elements and retrotransposons, which occurs after genome-wide epigenetic erasure during germ cell development. In this review, we summarise the biochemical properties of DNMT3L and discuss the possible mechanisms behind DNMT3L-mediated imprinting establishment and retrotransposon silencing in germ cells. We also discuss possible connections between DNMT3L and non-coding RNA-mediated epigenetic remodelling, the roles of DNMT3L in germ cell development and the implications in stem cell and cancer research.
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