期刊
BIOLOGY OF THE CELL
卷 103, 期 12, 页码 593-605出版社
WILEY
DOI: 10.1042/BC20110069
关键词
angiogenesis; endothelium; permeability; signalling; vascular endothelial growth factor (VEGF)
类别
资金
- Association pour la recherche sur le cancer
- Ligue nationale contre le cancer
- Centre national pour la recherche scientifique
- Fondation pour la recherche medicale
- Marie Curie European reintegration grant
- Universite Paris Descartes
The endothelial barrier controls the passage of fluids, nutrients and cells through the vascular wall. This physiological function is closely related to developmental and adult angiogenesis, blood pressure control, as well as immune responses. Moreover, cancer progression is frequently characterized by disorganized and leaky blood vessels. In this context, vascular permeability drives tumour-induced angiogenesis, blood flow disturbances, inflammatory cell infiltration and tumour cell extravasation. Although various molecules have been implicated, the vascular endothelial adhesion molecule, VE-cadherin (vascular endothelial cadherin), has emerged as a critical player involved in maintaining endothelial barrier integrity and homoeostasis. Indeed, VE-cadherin coordinates the endothelial cell-cell junctions through its adhesive and signalling properties. Of note, many angiogenic and inflammatory mediators released into the tumour microenvironnnent influence VE-cadherin behaviour. Therefore restoring VE-cadherin function could be one very promising target for vascular normalization in cancer therapies. In this review, we will mainly focus on recent discoveries concerning the molecular mechanisms involved in modulating VE-cadherin plasticity in cancer.
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