期刊
NEUROTOXICOLOGY AND TERATOLOGY
卷 22, 期 3, 页码 337-345出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0892-0362(00)00065-9
关键词
lead poisoning; lead exposure; adverse effects; reaction time; learning; associative ability; information-processing speed
资金
- NIEHS NIH HHS [ES-07457, ES-05950] Funding Source: Medline
Long-Evans rats exposed chronically to lead (Pb) acetate (0, 75, or 300 ppm) were tested as adults on an automated, three-choice visual discrimination task as parr of a larger study designed to elucidate the cognitive effects of developmental Pb exposure. Median adult BPb levels for the groups were <5, 20, and 36 mu g/dl. The pattern of results suggested a linear effect, with increasing lead dose producing progressively slower learning and an increased incidence of impaired individuals. This latter measure proved to be slightly more sensitive than the former, suggesting individual differences in susceptibility to ph neurotoxicity. Additional analyses revealed that the impairing effect of Pb was seen in both the chance and post-chance learning phases, indicating that the: deficit was not Limited to (but could include) attentional function. Reaction time on incorrect trials was reduced in the 300-ppm group. whereas no Pb effect was seen for correct trials. The present findings suggest that chronic developmental Pb exposure produces an associative deficit as well as a tendency to respond rapidly, but does not affect information-processing speed. (C) 2000 Elsevier Science Inc. All rights reserved.
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