期刊
IMMUNOLOGY TODAY
卷 21, 期 5, 页码 228-234出版社
ELSEVIER SCI LTD
DOI: 10.1016/S0167-5699(00)01596-6
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Natural killer (NK) cells can detect whether cells have undergone tumor transformation or viral infection. The discovery of specific inhibitory receptors for major histocompatibility complex class I molecules clarified the basis of this discrimination. However, the receptors responsible for NK-cell triggering in the process of natural cytotoxicity remained elusive until recently. Here, Alessandro Moretta and colleagues describe the identification and characterization of several such receptors.
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