期刊
BIOLOGY OF THE CELL
卷 102, 期 12, 页码 621-634出版社
WILEY
DOI: 10.1042/BC20100101
关键词
autophagy; bacteria; P62/sequestosome 1 (SQSTM1); pathogens; ubiquitin; xenophagy
类别
资金
- French Ministry of Research and Technology
- French Research National Agency [MIIM05, MIE09]
Bacterial infection relies on the micro-organism's ability to orchestrate the host's cell signalling such that the immune response is not activated. Conversely, the host cell has dedicated signalling pathways for coping with intrusions by pathogens. The autophagy of foreign micro-organisms (known as xenophagy) has emerged as one of the most powerful of these pathways, although the triggering mode remains largely unknown. In the present paper, we discuss the role that certain post-translational modifications (primarily ubiquitination) may play in the activation of xenophagy and how some bacteria have evolved mechanisms to subvert or hijack this process. In particular, we address the role played by P62/SQSTM1 (sequestosome 1). Finally, we discuss how autophagy can be subverted to eliminate bacteria-induced danger signals.
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