期刊
BIOLOGY OF THE CELL
卷 100, 期 11, 页码 617-631出版社
PORTLAND PRESS LTD
DOI: 10.1042/BC20080020
关键词
c-Abl; cancer; growth factor; signalling; tyrosine kinase
类别
资金
- CNRS (Centre National de la Recherche Scientifique)
- SERVIER Laboratories
- INCa (Institut National du Cancer)
- Inserm
c-Abl is a non-receptor tyrosine kinase which is localized both in the nucleus and cytoplasm, and is involved in the regulation of cell growth, survival and morphogenesis. Although c-Abl nuclear function has been extensively studied, recent data also indicate an important role in cytoplasmic signalling through mitogenic and adhesive receptors. Here, we review the mechanisms by which growth factors promote cytoplasmic c-Abl activation and signalling and its function in the induction of DNA synthesis, changes in cell morphology and receptor endocytosis. The importance of de-regulated c-Abl cytoplasmic signalling in solid tumours is also discussed.
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