期刊
BIOLOGY OF THE CELL
卷 100, 期 1, 页码 27-38出版社
WILEY
DOI: 10.1042/BC20070098
关键词
cell stress; internal ribosome entry segment (IRES); mRNA; polysome profiling; translation; translational re-programming
类别
There is now an overwhelming body of evidence to suggest that internal ribosome entry is required to maintain the expression of specific proteins during patho-physiological situations when cap-dependent translation is compromised, for example, following heat shock or during mitosis, hypoxia, differentiation and apoptosis. Translational profiling has been used by several groups to assess the extent to which alternative mechanisms of translation initiation selectively recruit mRNAs to polysomes during cell stress. The data from these studies have shown that under each condition 3-5% of coding mRNAs remain associated with the polysomes. Importantly, the genes identified in each of these studies do not show a significant amount of overlap, suggesting that 10-15% of all mRNAs have the capability for their initiation to occur via alternative mechanism(s).
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