相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol1-yl]-phenyl} acetamide (OSU-03012), a celecoxib derivative, directly targets p21-activated kinase
Leonardo M. Porchia et al.
MOLECULAR PHARMACOLOGY (2007)
PAK3 related mental disabillity:: Further characterization of the phenotype
Maarit Peippo et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2007)
Induction of vascular permeability:: βPIX and GIT1 scaffold the activation of extracellular signal-regulated kinase by PAK
Rebecca Stockton et al.
MOLECULAR BIOLOGY OF THE CELL (2007)
Specificity profiling of Pak kinases allows identification of novel phosphorylation sites
Ulrike E. E. Rennefahrt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Patterns of somatic mutation in human cancer genomes
Christopher Greenman et al.
NATURE (2007)
The kinase-inhibitory domain of p21-activated kinase 1 (PAK1) inhibits cell cycle progression independent of PAK1 kinase activity
M. Thullberg et al.
ONCOGENE (2007)
Crystal structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group IIPAKs
Jeyanthy Eswaran et al.
STRUCTURE (2007)
Multiple Rho proteins regulate the subcellular targeting of PAK5
Xiaochong Wu et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Novel FXXFF and FXXMF motifs in androgen receptor cofactors mediate high affinity and specific interactions with the ligand-binding domain
Dennis J. van de Wijngaart et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients
Caroline Holm et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2006)
PAK1 hyperactivation is sufficient for mammary gland tumor formation
R-A Wang et al.
ONCOGENE (2006)
Nucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic properties
S Cotteret et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
CRIPak, a novel endogenous Pak1 inhibitor
AH Talukder et al.
ONCOGENE (2006)
Targeting and activation of Rac1 are mediated by the exchange factor β-Pix
JP ten Klooster et al.
JOURNAL OF CELL BIOLOGY (2006)
Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease
LX Zhao et al.
NATURE NEUROSCIENCE (2006)
P21-activated kinase 1 regulation of estrogen receptor-α activation involves serine 305 activation linked with serine 118 phosphorylation
SK Rayala et al.
CANCER RESEARCH (2006)
Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors
A Beeser et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Pak4 induces premature senescence via a pathway requiring p16INK4/P19ARF and mitogen-activated protein kinase signaling
MS Cammarano et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Production and use of a cell permeable inhibitor of group A Paks (TAT-PID) to analyze signal transduction
A Beeser et al.
METHODS (2005)
Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3
JS Meng et al.
JOURNAL OF NEUROSCIENCE (2005)
Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase
R Kaur et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation
LJ Sundberg-Smith et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
GITI activates p21-activated kinase through a mechanism independent of p21 binding
TH Loo et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling
N Schrantz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
p21-activated kinase 2 in neutrophils can be regulated by phosphorylation at multiple sites and by a variety of protein phosphatases
Q Zhan et al.
JOURNAL OF IMMUNOLOGY (2003)
PAK4 kinase is essential for embryonic viability and for proper neuronal development
J Qu et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Targeted disruption of the gene for the PAK5 kinase in mice
XF Li et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Merlin, the product of the Nf2 tumor suppressor gene, the p21-activated is an inhibitor of kinase, Pak1
JL Kissil et al.
MOLECULAR CELL (2003)
Nischarin inhibits Rac induced migration and invasion of epithelial cells by affecting signaling cascades involving PAK
SK Alahari
EXPERIMENTAL CELL RESEARCH (2003)
X-linked mild non-syndromic mental retardation with neuropsychiatric problems and the missense mutation A365E in PAK3
AK Gedeon et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2003)
p21-activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD
S Cotteret et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
PAKI phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation
JK Slack-Davis et al.
JOURNAL OF CELL BIOLOGY (2003)
The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis
S Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
p21-activated kinase 1 (PAK1) interacts with the Grb2 adapter protein to couple to growth factor signaling
LA Puto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Death receptor-induced activation of initiator caspase 8 is antagonized by serine/threonine kinase PAK4
N Gnesutta et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK
PP Roux et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Rho GTPases in cell biology
S Etienne-Manneville et al.
NATURE (2002)
P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-α and promotes hyperplasia in mammary epithelium
RA Wang et al.
EMBO JOURNAL (2002)
Rac-PAK signaling stimulates extracellular signal- regulated kinase (ERK) activation by regulating formation of MEKI-ERK complexes
ST Eblen et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
The K252a derivatives, inhibitors for the PAK/MLK kinase family, selectively block the growth of RAS transformants
TV Nheu et al.
CANCER JOURNAL (2002)
p21-activated kinases: three more join the Pak
ZM Jaffer et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2002)
Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain
A Pandey et al.
ONCOGENE (2002)
A dominant-negative p65 PAK peptide inhibits angiogenesis
WB Kiosses et al.
CIRCULATION RESEARCH (2002)
The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family
CG Koh et al.
CURRENT BIOLOGY (2002)
Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines
MG Callow et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells
C Dan et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin
C Dan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Regulation of the p21-activated kinase (PAK) by a human Gβ-like WD-repeat protein, hPIP1
CZ Xia et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
The mechanism of PAK activation - Autophosphorylation events in both regulatory and kinase domains control activity
C Chong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6
F Yang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Activated PAK4 regulates cell adhesion and anchorage-independent growth
J Qu et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1)
CC King et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
M Lei et al.
CELL (2000)
The Akt proto-oncogene links Ras to Pak and cell survival signals
Y Tang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase
AK Howe et al.
NATURE CELL BIOLOGY (2000)
分享论文
