期刊
BIOLOGY OF THE CELL
卷 100, 期 1, 页码 63-70出版社
PORTLAND PRESS LTD
DOI: 10.1042/BC20070073
关键词
epigenetic mechanism; nuclear architecture; pseudoautosomal region 2 (PAR2); X chromosome inactivation; X-inactive-specific transcript
类别
资金
- Telethon [GGP02308] Funding Source: Medline
The compensation of the different level of transcripts of X-linked genes in male and female mammals is achieved through X chromosome inactivation, a complex process that differentially regulates the sex chromosomes of female cells. This mechanism has been dissected at evolutionary, genetic and molecular levels: here, we discuss some of the latest examples that illustrate better these intricate connections, focusing particularly on the emerging role of spatial and three-dimensional chromatin arrangements in the building of this special chromosome, the inactive X chromosome.
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