期刊
JOURNAL OF NUTRITION
卷 130, 期 5, 页码 1200-1203出版社
AMER INST NUTRITION
DOI: 10.1093/jn/130.5.1200
关键词
quercetin glucosides; flavonols; bioavailability; metabolism; humans
The flavonoid quercetin is an antioxidant which occurs in foods mainly as glycosides. The sugar moiety in quercetin glycosides affects their bioavailability in humans. Quercetin-3-rutinoside is an important form of quercetin in foods, but its bioavailability in humans is only 20% of that of quercetin-4'-glucoside. Quercetin-3-rutinoside can be transformed into quercetin-3-glucoside by splitting off a rhamnose molecule. We studied whether this 3-glucoside has the same high bioavailability as the quercetin-4'-glucoside. To that end we fed five healthy men and four healthy women (19-57 y) a single dose of 325 mu mol of pure quercetin-3-glucoside and a single dose of 331 mu mol of pure quercetin-4'-glucoside and followed the plasma quercetin concentrations. The bioavailability was the same for both quercetin glucosides, The mean peak plasma concentration of quercetin was 5.0 +/- 1.0 mu mol/L (+/-SE) after subjects had ingested quercetin-3-glucoside and 4.5 +/- 0.7 mu mol/L after quercetin-4'-glucoside consumption. Peak concentration was reached 37 +/- 12 min after ingestion of quercetin-3-glucoside and 27 +/- 5 min after quercetin-4'-glucoside, Half-life of elimination of quercetin from blood was 18.5 +/- 0.8 h after ingestion of quercetin-3-glucoside and 17.7 +/- 0.9 h after quercetin-4'-glucoside. We conclude that quercetin glucosides are rapidly absorbed in humans, irrespective of the position of the glucose moiety. Conversion of quercetin glycosides into glucosides is a promising strategy to enhance bioavailability of quercetin from foods.
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