期刊
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
卷 48, 期 5, 页码 558-559出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1532-5415.2000.tb05004.x
关键词
Alzheimer's disease; clinical dementia rating; reliability
资金
- NIA NIH HHS [AG05681, AG03991] Funding Source: Medline
OBJECTTVE: To test the interrater reliability of the Clinical Dementia Rating (CDR) in a multicenter clinical trial. DESIGN: Observational study. SETTING: Training session for a multicenter trial of milameline, a direct muscarinic agonist, in the treatment of Alzheimer's disease. PARTICIPANTS: Twenty-four raters (physicians and nurses) familiar with drug trials and expert in the care of patients with Alzheimer's disease. METHODS: Independent scoring of the CDR using four videotaped CDR interviews. OUTCOME MEASURE: Interrater reliability, as tested by the Kappa statistic. RESULTS: The overall interrater reliability was 0.62. Within the CDR domains, the global kappas ranged from 0.33 +/- 0.06 to 0.88 +/- 0.06. CONCLUSIONS: The data support moderate to high overall interrater reliability but show important difficulties in the reliable assessment of early dementia.
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