期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 28, 期 9, 页码 1328-1337出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0891-5849(00)00219-7
关键词
free radical; MAP kinases; T cells; thymocytes; P38; JNK; cytokines; NFAT
The mitogen-activated protein (MAP) kinase family members, which include the extracellular response kinases (ERK), p38, and c-Jun amino terminal kinases (JNK), play a role in mediating signals triggered by cytokines, growth factors, and environmental stress. JNK and p38 MAP kinases have been involved in inflammatory processes induced by a variety of stimuli, such as oxidative stress. Here, we describe the role of the JNK and p38 MAP kinase signaling pathways in the development of T cells in the thymus, and activation and differentiation of T cells in the peripheral immune system. (C) 2000 Elsevier Science Inc.
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