期刊
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
卷 49, 期 3, 页码 231-236出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0939-6411(00)00069-2
关键词
hydroxypropylmethylcellulose; cellulose ether; surface tension; molecular weight; viscosity; submicron emulsion; droplet size; laser diffractometry; ophthalmic application
Hydroxypropylmethylcellulose (HPMC) is a known emulsifier as well as a common viscosity enhancer in eye drops. Therefore, HPMC stabilized emulsions appear as interesting drug carriers for ophthalmic use and as a suitable treatment of dry eye syndrome. Since submicron emulsions are known to have an improved drug delivery, attempts were made to reduce the emulsion's droplet size by high-pressure homogenization. Droplet size was dependent on the homogenization pressure and the polymer content. Differences were found between emulsions stabilized with higher and lower molecular weight HPMC. Smaller droplet sizes were obtained with the shorter chained HPMC. No considerable influence of the substitution type was observed. (C) 2000 Elsevier Science B.V. All rights reserved.
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