期刊
THEORETICAL POPULATION BIOLOGY
卷 57, 期 3, 页码 265-271出版社
ACADEMIC PRESS INC
DOI: 10.1006/tpbi.2000.1452
关键词
polymorphism information content; uniformly minimum variance unbiased estimator; maximum likelihood estimator; multinomial distribution; heterozygosity
资金
- NCRR NIH HHS [RR03655] Funding Source: Medline
- NHLBI NIH HHS [HL55055] Funding Source: Medline
- NIGMS NIH HHS [GM28353] Funding Source: Medline
The polymorphism information content (PIC) value is commonly used in genetics as a measure of polymorphism for a marker locus used in linkage analysis. In this communication we have derived the uniformly minimum variance unbiased estimator of PIC along with its exact variance. We have also calculated the exact variance of the maximum likelihood estimator of PIC which is asymptotically an unbiased estimator. In order to find this variance we have derived a recursive formula to calculate the moments of any polynomial in a set of variables that are multinomially distributed. (C) 2000 academic Press.
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