期刊
DIGESTIVE DISEASES AND SCIENCES
卷 45, 期 5, 页码 946-951出版社
KLUWER ACADEMIC/PLENUM PUBL
DOI: 10.1023/A:1005529209427
关键词
cholera toxin; oral rehydration solutions; gum arabic; intestine; sodium transport; water transport
Gum arabic (GA), a soluble fiber with emulsifying properties, enhances intestinal water and electrolyte absorption in normal and secreting rats. Our aim was to assess the effect of GA, 2.5 and 5.0 g/liter, on cholera toxin-induced water and electrolyte secretion in rat jejunum in vivo. After a 2-hr exposure to cholera toxin. jejunal segments of adult rats were perfused in vivo with a plasma electrolyte solution containing GA, 0, 2.5 or 5.0 g/liter. Na-24 was used as a marker of sodium influx. Cholera toxin-induced secretion was reduced by GA, 2.5 and 5.0 g/liter. Na-24 secretion into the lumen was reduced by GA. GA caused a morphological expansion of intercellular spaces in the villi but not crypts. In conclusion, GA promotes lumen to blood intestinal transport of water and sodium despite cholera toxin activation. These observations support a potential role for GA in enhancing the efficacy of ORS.
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