期刊
BIOLOGY OF REPRODUCTION
卷 85, 期 1, 页码 189-197出版社
OXFORD UNIV PRESS INC
DOI: 10.1095/biolreprod.110.089458
关键词
Lin28; microRNAs; Mirlet7 family; retinoic acid; spermatogonial differentiation
资金
- National Institutes of Health [HD10808]
Spermatogonial differentiation is orchestrated by the precise control of gene expression involving retinoic acid signaling. MicroRNAs have emerged as important regulators of spermatogenesis, and here we show that the Mirlet7 family miRNAs are expressed in mouse spermatogonia and spermatocytes. Retinoic acid significantly leads to the induction of Mirlet7 miRNAs through suppression of Lin28. We further confirmed both in vitro and in vivo that expressions of Mycn, Ccnd1, and Col1a2, which are targets of Mirlet7, were downregulated during spermatogonial differentiation. These results suggest that Mirlet7 family miRNAs play a role in retinoic acid-induced spermatogonial differentiation.
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