期刊
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 48, 期 5, 页码 1738-1745出版社
AMER CHEMICAL SOC
DOI: 10.1021/jf990665o
关键词
Vitis vinifera; flavan-3-ols; procyanidins; radical scavenger; antioxidant; ABTS radical; X-irradiation; radioprotection; anticlastogen
The quantitative distribution of several flavan-3-ols was determined using HPLC in a grape (Vitis vinifera) seed extract (GSE) of four cultivars grown In the region of Murcia. Polymer greater than or equal to C-4 units made up the largest group of procyanidins in the GSE (90.92%, expressed as HBLC % area). The antioxidant activity of GSE and other reference compounds was investigated by measuring their ability to scavenge the ABTS(.)+ radical cat ion (TEAC). The most effective compounds were, in order: GSE > rutin > (+)-catechin > diosmin greater than or equal to ascorbic acid. The radioprotective effects of GSE and other reference compounds were determined by using the micronucleus test for anticlastogenic activity, any reduction of the frequency of micronucleated polychromatic erythrocytes (MnPCEs) being evaluated in the bone marrow of mouse exposed to X-rays. The most effective compounds were, in order: GSE > rutin > dimethyl sulfoxide (DMSO) > ascorbic acid > 6-n-propyl-2-thiouracil-6c (PTU) > diosmin. The higher ABTS(.)+ scavenging capacity and anticlastogenic activity of GSE can be explained, structurally, by the high number of conjugated structures between the catechol groups in the B-rings and the 3-OH free groups of the polymeric polyphenolic skeleton and, in addition, by the stability of the aroxyl flavonoid radical generated in the above processes.
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