期刊
GENE
卷 248, 期 1-2, 页码 1-14出版社
ELSEVIER
DOI: 10.1016/S0378-1119(00)00139-6
关键词
cullin; NEDD8; protein modification; sentrin; SUMO; ubiquitin
Ubiquitin is a small polypeptide that covalently modifies other cellular proteins and targets them to the proteasome for degradation. In recent years, ubiquitin-dependent proteolysis has been demonstrated to play a critical role in the regulation of many cellular processes, such as cell cycle progression, cell signaling, and immune recognition. The recent discovery of three new ubiquitin-like proteins, NEDD8, Sentrin/SUMO, and Apg12, has further broadened the horizon of this type of post-translational protein modification. This review will focus on the biology and biochemistry of the Sentrin/SUMO and NEDD8 modification pathways, which are clearly distinct from the ubiquitination pathway and have unique biological functions. (C) 2000 Elsevier Science B.V. All rights reserved.
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