期刊
NEUROLOGY
卷 54, 期 9, 页码 1859-1861出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.54.9.1859
关键词
multiple sclerosis; optic neuritis; human leukocyte antigen
资金
- NEI NIH HHS [EY05435] Funding Source: Medline
- NINDS NIH HHS [NS26799] Funding Source: Medline
The association of the human leukocyte antigen (HLA)-DR2 allele with brain MRI signal. abnormalities and with the development of MS was assessed in 178 patients enrolled in the Optic Neuritis Treatment Trial. HLA haplotype DR2 was present in 85 (48%) of the 178 patients. Its presence was associated with increased odds of probable or definite MS at 5 years (odds ratio, 1.92; 95% confidence interval, 1.01 to 3.67; p = 0.04). The association was most apparent among patients with signal abnormalities on baseline brain MRI.
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