期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 396, 期 1, 页码 39-42出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-2999(00)00207-7
关键词
cannabinoid; capsaicin; neuron; afferent; pain; receptor; sensory; vasodilation
The possibility that the anandamide transport inhibitor N-(4-hydroxyphenyl)-5,8,11,14-eicosatetraenamide (AM404), structurally similar to the vanilloid receptor agonists anandamide and capsaicin, may also activate vanilloid receptors and cause vasodilation was examined. AM404 evoked concentration-dependent relaxations in segments of rat isolated hepatic artery contracted with phenylephrine. Relaxations were abolished in preparations pre-treated with capsaicin. The calcitonin-gene related peptide (CGRP) receptor antagonist CGRP-(8-37) also abolished relaxations. The vanilloid receptor antagonist capsazepine inhibited vasodilation by AM404 and blocked AM404-induced currents in patch-clamp experiments on Xenopus oocytes expressing the vanilloid subtype 1 receptor (VRI). In conclusion, AM404 activates native and cloned vanilloid receptors. (C) 2000 Elsevier Science B.V. All rights reserved.
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