Facile access to N-thiazolyl α-amino acids from α-bromo ketones and α-amino acids

N-Substituted 2-aminothiazoles are synthesized in a one-pot procedure using readily available alpha-bromo ketones and amines. This method is compatible with a wide range of functional groups and offers a facile and efficient access to the class of N-thiazolyl alpha-amino acid derivatives. (C) 2000 Elsevier Science Ltd. All rights reserved.