期刊
CELL
卷 101, 期 4, 页码 353-363出版社
CELL PRESS
DOI: 10.1016/S0092-8674(00)80846-6
关键词
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资金
- NIGMS NIH HHS [F32GM17612] Funding Source: Medline
Bacterial pathogens of plants and animals utilize conserved type III delivery systems to traffic effector proteins into host cells. Plant innate immune systems evolved disease resistance (R) genes to recognize some type III effecters, termed avirulence (Avr) proteins. On disease-susceptible (r) plants, Avr proteins can contribute to pathogen virulence. We demonstrate that several type III effecters from Pseudomonas syringae are targeted to the host plasma membrane and that efficient membrane association enhances function. Efficient localization of three Avr proteins requires consensus myristoylation sites, and Avr proteins can be myristoylated inside the host cell. These prokaryotic type III effecters thus utilize a eukaryote-specific posttranslational modification to access the subcellular compartment where they function.
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