期刊
NEUROSCIENCE LETTERS
卷 285, 期 2, 页码 99-102出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3940(00)01035-1
关键词
linoleic acid; alpha-linolenic acid; arachidonic acid; eicosapentaenoic acid; docosahexaenoic acid; nerve growth factor; hippocampus
Dietary deprivation of alpha-linolenic acid (n-3) through two generations has been shown to lower performance in an operant-type brightness-discrimination learning test in rats. Here, we examined a possible correlation between nerve growth factor (NGF) content and n-3 fatty acid status in the brain. Female rats were fed a semipurified diet supplemented with safflower oil (n-3 fatty acid-deficient) and their offsprings were fed a diet supplemented with either 3% safflower oil (Saf group) or a mixture of 2.4% safflower oil plus 0.6% ethyl eicosapentaenoate (Saf + EPA group) after weaning. The brain docosahexaenoic acid (22:6n-3, DHA) content in the Saf group was less than half of that in the Per group fed a diet supplemented with 3% perilla oil (n-3 fatty acid-sufficient) throughout the duration of the experiment. The DHA level of the Saf + EPA group was restored to the level of the Per group. However, the NGF contents in the hippocampus of the Saf and Saf + EPA groups were half that of the Per group. In the piriform cortex, the NGF content tended to be higher in the Saf and Saf + EPA groups than in the Per group. These results indicate that dietary n-3 fatty acid deficiency and restoration affect NGF levels differently among different brain regions. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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