期刊
SCIENCE
卷 288, 期 5468, 页码 1026-1029出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.288.5468.1026
关键词
-
资金
- NHGRI NIH HHS [HG01597] Funding Source: Medline
A nanofluidic channel device, consisting of many entropic traps, was designed and fabricated for the separation of Long DNA molecules. The channel comprises narrow constrictions and wider regions that cause size-dependent trapping of DNA at the onset of a constriction. This process creates electrophoretic mobility differences, thus enabling efficient separation without the use of a gel matrix or pulsed electric fields. Samples of Long DNA molecules (5000 to similar to 160,000 base pairs) were efficiently separated into bands in 15-millimeter-long channels. Multiple-channel devices operating in parallel were demonstrated. The efficiency, compactness, and ease of fabrication of the device suggest the possibility of more practical integrated DNA analysis systems.
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