期刊
JOURNAL OF CONTROLLED RELEASE
卷 66, 期 2-3, 页码 127-133出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0168-3659(99)00262-X
关键词
iontophoresis; electroporation; calcitonin; parathyroid hormone; skin transport
资金
- NCI NIH HHS [R01 CA71347] Funding Source: Medline
- NIAMS NIH HHS [1 R43 AR44794] Funding Source: Medline
Electrically-assisted delivery by iontophoresis and/or electroporation was used in vitro to deliver the calcium regulating hormones, salmon calcitonin (sCT) and parathyroid hormone (1-34) (PTH) through human epidermis. Such delivery could be useful for chronic treatment of post-menopausal osteoporosis and other clinical indications as a superior alternative to parenteral delivery, sCT (50 mu g/ml) or PTH (1-34) (100 mu g/ml) formulation was prepared in citrate buffer (pH 4.0 or 5.0, respectively). Epidermis separated from human cadaver skin was used, Iontophoresis was applied using a constant current power source and electroporation with an exponential pulse generator. Silver/silver chloride electrodes were used. A combination of electroporation and iontophoresis resulted in higher transdermal permeation than either one technique alone. Electroporation also shortened the lag time of iontophoretic transdermal delivery of salmon calcitonin. Pulsing at lower voltages followed by iontophoresis did not result in increased transport (over iontophoresis alone), perhaps because the transdermal voltage was very low. The transdermal transport of salmon calcitonin by pulsing with 15 pulses (1 ppm) of 500 V (200 ms) followed by iontophoresis led to a quick input and high flux. The average transdermal voltage was only about 50 V for a 500 V study. (C) 2000 Elsevier Science B.V. All rights reserved.
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