期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 191, 期 10, 页码 1799-1806出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.191.10.1799
关键词
multiple sclerosis; nonhuman primate; interferon gamma; interleukin 10; growth factors
资金
- NIAID NIH HHS [R01 AI043073, AI43073-06] Funding Source: Medline
Multiple sclerosis is a demyelinating disorder of the central nervous system (CNS), in which an immune attack directed against myelin constituents causes myelin destruction and death oligodendrocytes, the meylin-producing cells. Here, the efficacy of nerve growth factor (NGF), a growth factor for neurons and oligodendrocytes, in promoting myelin repair was evaluated using the demyelinating model of experimental allergic encephalomyelitis (EAE) in the common marmoset. Surprisingly, we found that NGF delayed the onset of clinical EAE and, pathologically, prevented the full development of EAE lesions. We demonstrate by immunocytochemistry that NGF exerts its antiinflammatory effect by downregulating the production of interferon gamma by T cells infiltrating the CNS, and upregulating the production of interleukin 10 by glial cells in both inflammatory lesions of EAE and normal-appearing CNS white matter. Thus, NGF, currently under investigation in human clinical trials as a neuronal trophic factor, may be an attractive candidate for therapy of autoimmune demyelinating disorders.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据