期刊
AIDS RESEARCH AND HUMAN RETROVIRUSES
卷 16, 期 8, 页码 741-749出版社
MARY ANN LIEBERT INC PUBL
DOI: 10.1089/088922200308747
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资金
- NIAID NIH HHS [AI41851, AI40895] Funding Source: Medline
A previous study implicated a conserved surface of the human immunodeficiency virus (HIV-1) gp120 exterior envelope glycoprotein in binding the CCR5 viral coreceptor (Rizzuto C, Wyatt R, Hernandez-Ramos N, Sun Y, Kwong PD, Hendrickson WA, and Sodroski J: Science 1998;280:1949-1953). Additional mutagenesis indicates that important residues in this region for CCR5 binding are Ile-420, Lys-421, Gln-422, Pro-438, and Gly-441, These highly conserved residues are located on two strands that connect the gp120 bridging sheet and outer domain, suggesting a mechanism whereby interdomain conformational shifts induced by CD4 binding could facilitate CCR5 binding.
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