期刊
BIOLOGY OF REPRODUCTION
卷 81, 期 3, 页码 488-496出版社
OXFORD UNIV PRESS INC
DOI: 10.1095/biolreprod.108.075259
关键词
anterior pituitary; Cre/loxP; estradiol; estradiol receptor; gonadotropin-releasing hormone; luteinizing hormone; ovary; ovulatory cycle
资金
- National Institutes of Health [R01 HD44608, HD933067, HD370246]
- Eunice Kennedy Shriver NICHD/NIH [U54 HD58820]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R01HD044608] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [K08DK069518, P60DK079637] Funding Source: NIH RePORTER
Mice lacking estrogen receptor alpha in the pituitary gonadotroph (PitEsr1KO) were generated to determine the physiologic role of pituitary estrogen signaling in the reproductive axis. PitEsr1KO female mice are subfertile or infertile and have elevated levels of serum luteinizing hormone (LH) and LH beta subunit gene expression, reflecting a lack of estrogen negative feedback effect on the gonadotroph. While serum LH values are elevated in PitEsr1KO mice, the degree of elevation is much less than that observed in ESR1-null mice, indicating that the hypothalamus must also have an important role in estrogen negative feedback. PitEsr1KO mice also demonstrate a defect in estrogen positive feedback, as surge LH values and estrous cyclicity are absent in these mice. Although sex steroid feedback in the reproductive axis is thought to involve discrete anatomic regions that mediate either a positive or negative estrogen effect, PitEsr1KO mice demonstrate novel evidence that localizes both estrogen positive feedback and estrogen negative feedback to the gonadotroph, which suggests that they may be mechanistically related.
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