期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 163, 期 1-2, 页码 89-93出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0303-7207(99)00244-0
关键词
IGFs; ovarian folliculogenesis; mammals
In the primate ovary, androgens promote oocyte insulin-like growth factor (IGF) I expression as well as initiation of follicle development. In most other mammals, IGFs do not appear to be required for the entry of follicles into the pool of growing follicles and for their gonadotropin-independent development. In contrast, IGFs are involved in the increase in FSH-responsiveness of granulosa cells when follicles enter into the gonadotropin-dependent stages of follicular development (200 mu m in mouse, 2 mm in sheep, 5 mm diameter in cattle). In the late stages of folliculogenesis, the decrease in IGFBPs participates in the increase in IGF bioavailability, leading to a further amplification of FSH action. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据