期刊
NEUROSCIENCE LETTERS
卷 286, 期 1, 页码 69-73出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(00)01090-9
关键词
Lewy body; dementia with Lewy bodies; alpha-synuclein; immunohistochemistry; degeneration process; microglia; astroglia; complement
We investigated the degeneration process of Lewy bodies (LB) in the brains of dementia with Lewy bodies, using alpha-synuclein-immunohistochemistry. Intracellular LB, LB-related neurites and some extracellular LB were positively immunostained with anti-alpha-synuclein antibodies. Concentric LB-bearing neurons had no microglial involvement, while degenerated neurons with ill-defined LB displayed intense microglial involvement. The late stage of extracellular LB were immunoelectron-microscopically composed of loose aggregates of filamentous components with lost alpha-synuclein-immunoreactivity and penetrated astroglial processes. These findings suggest that microglias are involved during the stages from degenerated LB-bearing neurons to extracellular LB, while astroglias are involved during the stage of extracellular LB, Some intracellular LB were positive for anti-C3d and -C4d antibodies, suggesting that the classical complement pathway is activated in degenerated LB-bearing neurons, inducing microglial activation and neuronal death. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.
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