期刊
MOLECULAR BRAIN RESEARCH
卷 78, 期 1-2, 页码 154-162出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0169-328X(00)00088-7
关键词
cognitive deficits; LTP; memory; NMDA; caloric restriction; glutamate
资金
- NIA NIH HHS [AG 04418] Funding Source: Medline
A major focus of aging research has been the search for treatments that will prevent or ameliorate the memory deficits associated with aging. One paradigm, lifelong caloric restriction, has been reported to reduce some of the effects of aging. In the current report, we examined the effects of this treatment on age-related deficits in LTP, a putative cellular building block for memory formation. We report here that lifelong caloric restriction completely prevents the age-related deficit in LTP. In addition, we report that there is a dramatic decrease in the expression of the NMDA receptor subunit NR1 in aged rats and this age-related defect is also prevented by caloric restriction. These data provide a molecular and cellular mechanism by which life long caloric restriction may ameliorate some of the cognitive deficits associated with the aging process. (C) 2000 Published by Elsevier Science B.V.
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