期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
卷 1475, 期 1, 页码 5-9出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0304-4165(00)00050-7
关键词
calpain-3; m-calpain; cancer cachexia; protein turnover; skeletal muscle; proteasome; ubiquitin
The Yoshida AH-130 rat ascites hepatoma is a model system for studying the mechanisms involved in the protein hypercatabolism associated with cancer cachexia. The present study was aimed at investigating if the calpain-3 gene expression in skeletal muscle was affected by tumor growth. The results presented clearly show that calpain-3 gene expression is considerably reduced in experimental cancer cachexia, while there is a reciprocal change in the expression of the ubiquitin-dependent proteolytic system and in the ubiquitous m-calpain. The results, observed during cancer cachexia, suggest a potential counterregulatory role of calpain-3 in muscle proteolysis. (C) 2000 Elsevier Science B.V. All rights reserved.
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