期刊
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
卷 10, 期 4, 页码 305-309出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0928-0987(00)00081-6
关键词
solid lipid nanospheres; paclitaxel; DSC; colloidal carriers
The study describes the development of stealth and non-stealth solid lipid nanospheres (SLNs) as colloidal carriers for paclitaxel, a drug with very low solubility. SLNs are constituted mainly of bioacceptable and biodegradable lipids, such as tripalmitin and phosphatidylcholine, and can incorporate amounts of paclitaxel up to 2.8%. Stealth and non-stealth loaded SLNs are in the nanometer size range and can be sterilized and freeze-dried. Thermal analysis (differential scanning calorimetry) showed that paclitaxel is not able to crystallize in the SLNs. Release of paclitaxel from SLNs is very low. Non-stealth and stealth SLNs are stable over time without precipitation of paclitaxel and can be proposed for its parenteral administration. (C) 2000 Elsevier Science B.V. All rights reserved.
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