期刊
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
卷 45, 期 6, 页码 887-890出版社
OXFORD UNIV PRESS
DOI: 10.1093/jac/45.6.887
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Twenty-five different Staphylococcus aureus strains that are widespread in France were screened by various methods for heterogeneous and low-level resistance to vancomycin. Population analysis on brain-heart infusion agar containing 4 mg/L of the drug detected resistant cells at frequencies of 10(-7) to 10(-6) in five multiply resistant strains. There was no antagonism between vancomycin and beta-lactam antibiotics. One of the five strains, isolated in 1993, was considered a putative progenitor of a French nosocomial S. aureus strain isolated in 1998 and for which the vancomycin MIC was 8 mg/L.
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