期刊
CELLULAR SIGNALLING
卷 12, 期 6, 页码 361-366出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0898-6568(00)00082-6
关键词
parathyroid hormone; G protein; calcium homeostasis; brain; K+ channel; nonselective cation channel
类别
资金
- NIDDK NIH HHS [DK41415, DK52005, DK48330] Funding Source: Medline
The extracellular Ca2+ (Ca-o(2+))-sensing receptor (CaR) critically influences Ca-o(2+) homeostasis by regulating parathyroid hormone (PTH) secretion and renal Ca2+ handling. Moreover, its expression in intestinal and bone cells suggests roles in all of the organs involved in maintaining systemic Ca-o(2+) homeostasis. This G-protein coupled receptor is also expressed in a wide variety of additional cells throughout the body. While our understanding of its role(s) outside of the system governing Ca-o(2+) metabolism remains rudimentary, the CaR will probably emerge as a versatile regulator of diverse cellular functions, including proliferation, differentiation, apoptosis, gene expression and maintenance of membrane potential. Finally, the recently developed, calcimimetic CaR activators, exemplified by a NPS R-467 and NPS R-568, provide novel approaches to treating diseases that previously had no effective medical therapies: topic likewise covered in this review. (C) 2000 Published by Elsevier Science Inc. All rights reserved.
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