期刊
BIOLOGY OF REPRODUCTION
卷 79, 期 1, 页码 51-57出版社
OXFORD UNIV PRESS INC
DOI: 10.1095/biolreprod.108.068072
关键词
gametogenesis; gene regulation; male reproductive tract; piRNA; spermatogenesis; testis; transposon
资金
- NICHD NIH HHS [R01 HD035494-09, R01 HD035494, HD 28832, R01 HD010808] Funding Source: Medline
The mammalian testis expresses a class of small noncoding RNAs that interact with mammalian PIWI proteins. In mice, the PIWI-interacting RNAs (piRNAs) partner with mammalian PIWI proteins, PIWIL1 and PIWIL2, also known as MIWI and MILI, to maintain transposon silencing in the germline genome. Here, we demonstrate that inactivation of Nct1/2, two noncoding RNAs encoding piRNAs, leads to derepression of LINE-1 (L1) but does not affect mouse viability, spermatogenesis, testicular gene expression, or fertility. These findings indicate that piRNAs from a cluster on chromosome 2 are necessary to maintain transposon silencing.
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