期刊
INTERNATIONAL IMMUNOLOGY
卷 12, 期 6, 页码 807-815出版社
OXFORD UNIV PRESS
DOI: 10.1093/intimm/12.6.807
关键词
adjuvant; in vivo animal models; primary response; T(h)1/T(h)2
类别
The induction of immune responses in vivo is typically performed with antigens administered in external adjuvants, like alum, complete Freund's adjuvant, LPS and, more recently, monophosphoryl lipid A (MPL), However, the role of the adjuvant is still poorly defined. The aim of this study was to test whether the MPL affects the function of antigen-presenting cells (APC) in vitro and In vivo. Antigen-pulsed APC [including macrophages, B cells and dendritic cells (DC)] were incubated or not with MPL, and their ability to sensitize naive T cells was tested in vitro and In vivo. The data show that MPL enhances the ability of macrophages and B cells to sensitize naive T cells, and confers to them the capacity to induce the development of T(h)1 and T(h)2. Administration of MPL i.v. In mice results in the redistribution of fully mature DC in the T cell area of the spleen, These observations suggest that MPL may induce an antigen-specific primary immune response by provoking the migration and maturation of DC that are the physiological adjuvant of the immune system.
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