期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 109, 期 4, 页码 770-772出版社
BLACKWELL SCIENCE LTD
DOI: 10.1046/j.1365-2141.2000.02083.x
关键词
peripheral blood progenitor cell mobilization; filgrastim; normal donors; granulocyte colony-stimulating factor; leukapheresis
类别
Eighty-one first-time normal donors underwent leukapheresis for peripheral blood progenitor cell (PBPC) collection after mobilization with filgrastim administered either twice-daily (6 mu g/kg every 12 h; n = 40) or once-daily (12 mu g/kg; n = 41) subcutaneously for 3 d. The groups were similar for age, donor blood volume and target CD34(+) cell dose to be collected (greater than or equal to 4 x 10(6) CD34(+) cells/kg recipient). There was no statistically significant difference in the apheresis yield of CD34(+) PBPCs (x 10(6)) per kg recipient weight (5.6 +/- 3.3 vs. 5.6 +/- 4.3; P = 0.94) and per litre of blood processed (30 +/- 17.2 vs. 30.4 +/- 19.5; P = 0.92).
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